He was ordained as Deacon on 30th January 1973 by Paulose Mar Philexinos, Metropolitan of Kandanadu diocese. He was ordained as a Priest on 23 May 1986 by Catholicos Baselius Paulose II of the Malankara Church (Jacobite Faction). His ordination as monk was on 22 December 1990 by Ignatius Zaka I, Patriarch of Antioch of the Universal Syrian Orthodox Church. He was ordained as a Metropolitan on 23 December 1990 by Ignatius Zaka I, Patriarch of Antioch of the Universal Syrian Orthodox Church. He was given the charge of Thrissur Diocese. Mar Meletios was one of the three Bishops from the Patriarch faction to accept the constitution of the Malankara Orthodox Church and move to the Orthodox faction. He was involved in controversy when he was one of the bishops to have consecrated a defected Bishop from the Syriac orthodox church in 2007, without the consent of the Episcopal Synod of the Church. The consecration was in contention also due to the lack of three bishops needed for a canonical consecration. The Synod approved the consecration in a later meeting. However, in a subsequent action the Synod de-recognised the said Metropolitan.
He was a teacher at St. Aprem Syrian Orthodox Theological Seminary, Damascus for one year. He was a teacher at MSOT Seminary, Malelcruz. He was a teacher at MSOT Seminary, Vettickal, Mulanthuruthy. Parishes in which he served as vicar are St.Mary's Church, Valamboor, St. Ignatius Church, Dallas, TX, USA. He was the President SOYA for 5 years. He was a member of NCCI, CASA National Board, CASA South Region and President of OCYM.
As a bishop Mar Meletius travelled to Turkey, USA, Canada, Vatican, Italy, UK, Sweden, Rumania, Germany, Holland, Austria, Sri Lanka, Samoa, Australia, South Africa, Singapore, Malaysia, and Gulf countries. As of 2015 He lived in Gedseemon Bishop's House, Mannuthy, Thrissur, Kerala, India.